Neutrophil gelatinase-associated lipocalin and oxidative stress markers based -scores to improve the diagnostic accuracy of chronic kidney diseases

Document Type : Original Article

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1 Chemistry Department, Faculty of Science, Damietta University, Damietta, Egypt

2 Chemistry Department, Faculty of Science, Helwan University, Cairo, Egypt

Abstract

Background: Biomarkers can detect chronic kidney disease (CKD) in an early stage. Patients and methods: 75 individuals suffering from chronic kidney disorders were included in this study. Serum Neutrophil gelatinase-associated lipocalin (NGAL) was assayed using ELISA. Nitric oxide (NO) in addition to total antioxidant capacity (TAC) was colorimetrically measured.  Results: NGAL was the most efficient marker among others. Its area under the receiver operating characteristic (ROC) were 0.91 and 0.80 for differentiating patients with CKD from control individuals and discriminating patients in late stages from those in early stages, respectively. The stepwise multivariate discriminant analysis (MDA) selected two novel indexes. The first is to differentiate patients in late stages from those in early stages of CKD; namely NGAL- Total antioxidant capacity (NT) score. The second is to differentiate all of these patients from those of the control subjects; namely NGAL- nitric oxide (NN) score. The AUCs of NT and NN scores were 0. 84 and 0.93; respectively. Conclusion: NT and NN scores may add more in the evaluation and prediction of the progression of CKD.

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