Ameliorating effect of propolis and moringa extract against equigan induced neurotoxicity and oxidative stress on rat hippocampus.

Document Type : Original Article

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Zoology Department, Faculty of Science, Tanta University, Tanta 31527, Egypt

Abstract

In most countries worldwide, Equigan is anabolic steroid that is forbidden for human uses or for meat production. The present study was designed to investigate the ameliorating role of Propolis and moringa leaf extract (MLE) against Equigan induced neurotoxicity and oxidative stress on rat hippocampus. A total of 48 healthy male albino rats weighing 170-200 g and of 10-12 weeks age were divided into 6 groups (8 animals each). 1st Control group includes animals that injected intramuscularly with olive oil for 12 weeks. 2nd and 3rd groups were rats received Propolis and MLE respectively. 4th experimental group include animals that receive intramuscular injections of Equigan for 12 weeks; 5th and 6th groups where rats intramuscular injected with Equigan and treated with Propolis and MLE at the same time respectively. The obtained results indicate that hippocampal nitric oxide (NO), malondialdehyde (MDA), acetylcholine esterase (AChE) and total protein were significantly increased in Equigan group when compared with control group. In contrast hippocampal catalase, SOD and total thiol levels were significantly decreased in Equigan group when compared with control group. On the other hand hippocampal NO, MDA, ACE and total protein in Equigan group were significantly increased when compared with co-treated Equigan with MLE or Propolis groups. In contrast; hippocampal catalase, SOD and total thiol levels were significantly decreased in Equigan group when compared with co-treated Equigan with MLE or propolis groups. We can concluded that; MLE and propolis extract ameliorate the neurotoxicity and oxidative stress on rat hippocampus induces by Equigan.

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