Potential hepatoprotection exerted by ginseng against chlorpyrifos-induced hepatotoxicity in albino rats.

Document Type : Original Article

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Dept.of Zoology, Faculty of Science, Menoufia University, Shebin El-Kom, Egypt

Abstract

Insecticides gained public reputation and widespread application to control the spread of different insects in various habitats. However, the deleterious effects of these chemicals could not be ignored and should be dealt seriously. The present work was conducted to test the efficacy of the natural plant ginseng in alleviating toxicity of chlorpyrifos. The organophosphorus insecticide chlorpyrifos induced hepatotoxicity and changes in some serum biochemical parameters. The liver of rats administered chlorpyrifos manifested cytoplasmic vacuolization, leucocytic infiltration, hemorrhage and remarkable dilatation of veins. The nuclear chromatin was condensed. There was a significant increase in alanin aminotransferase (ALT) while there was a significant decrease in albumin, catalase (CAT) and superoxide dismutase (SOD) in the serum of treated rats. Treating animals with ginseng was found in this study to alleviate hepatotoxicity and restore the levels of the tested serum parameters to nearly normal values.

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