Comparative cardioprotective effect of Egyptian Silybum marianum extract and Chinese silymarin in experimentally liver fibrosis.

Tousson, Ehab; Salama, Afrah F.; Dora, Mona A.; Elony, Mahmoud A.

doi:10.21608/jbaar.2016.106913

Comparative cardioprotective effect of Egyptian Silybum marianum extract and Chinese silymarin in experimentally liver fibrosis.

Document Type : Original Article

Authors

¹ Department of Zoology, Faculty of Science, Tanta University, Egypt.

² Biochemistry Section, Department of Chemistry, Faculty of Science, Tanta University, Egypt.

³ Botany Department, Faculty of Science, Tanta University, Egypt

10.21608/jbaar.2016.106913

Abstract

Liver fibrosis is one of the common problems effects on the human health. Many herbal, medicinal and pharmaceutical plants and their extracts are widely studied by many researches. Chinese silymarin got a bright reputation in relieve of liver fibrosis. The current study is a comparative study between the effect of Chinese silymarin (commercial drug) and the extracted silymarin from the natural Egyptian plant on the cardiac toxicity due to liver fibrosis induced by ethanol in rats. A total of 72 female Albino rats were divided into six groups; G1, Control; G2,Fibrosis; G3,Chinese silymarin; G4, Fibrosis + Chinese silymarin; G5, Egyptian silymarin extract; G6, Fibrosis + Egyptian silymarin extract. Results showed that, heart enzymes activities LDH, lipid profiles in serum and MDA in tissues were a significant increase in Fibrosis group when compared with control group. On the other hand; creatine kinase (CK) in serum, total protein, total thiol, TAC, CAT and GST in cardiac tissues were a significant decrease in Fibrosis group when compared with control group. The current results revealed that; the Egyptian plant extract improved the lipid profile, heart functions and its oxidative stress parameters as comparison with the used medical Chinese silymarin.

Keywords