Ameliorative effect of ginger extract against pathological alterations induced in mice bearing solid tumors.

Document Type : Original Article

Authors

1 Animal Biotechnology Department, Genetic Engineering & Biotechnology Institute, Sadat City University , Sadat City, Menoufia Province, Egypt.

2 Zoology Department, Faculty of Science, Menoufia University, Shebin Elkom, Menoufia Province, Egypt.

Abstract

This study was prepared to explore the effect of ginger extract in defeating the Ehrlich Ascites Carcinoma (EAC) injected subcutaneously in mice and induced solid tumour. After the solid tumour formation; the mice were classified into four groups (control, tumour untreated, ginger and ginger & tumour). Eight mice were grouped separately in each cage. Mice were killed and dissected at the end of this investigation; liver and kidney were removed for histopathological study. The biochemical parameters (ALT, AST, Urea, Creatinine, MDA, SOD and CAT) were measured in the sera of all tested groups. Ginger extract ameliorated the histological structures of both liver and kidney to be near to control, modulated the elevated values of (ALT, AST, Urea, Creatinine and MDA) and reduced values of (SOD and CAT) to record slightly normal readings. Tumour volumes reduced significantly and the destructed genomic DNA retained the normal pattern. Ginger has no pathological effects on control mice.

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