Biochemical and Histopatholigcal changes in Egyptian patients with Hepatitis C and Bilharziasis.

Document Type : Original Article

Authors

1 Molecular biology Dept., Genetic Engineering and Biotechnology research Institute (GEBRI), University of Sadat City

2 Public health and community medicine Dept., Faculty of Medicine, Benha University

3 Bioinformatics Dept., Genetic Engineering and Biotechnology research Institute (GEBRI), University of Sadat City.

4 Environmental Biotechnology Dept., Genetic Engineering and Biotechnology research Institute (GEBRI), University of Sadat City

Abstract

Viral hepatitis and infection with Schistosma mansoni are the main causes of chronic liver disease and liver cirrhosis. Infection with hepatitis C virus (HCV) is the most important public health problem in Egypt. This study was done to determine the association between Schistosma and hepatitis C, by testing liver function using the following biochemical tests: Total and direct bilirubin, TB-DB, alanine transaminase (ALT), aspartate transaminase (AST), alkaline phosphatase (ALP), serum albumin, and liver biopsy, and make comparison between them. The results indicated that 60 % of cases HCV and Bilharzias reveal abnormal results accompanied by chronic liver disease, when compared to the 40% of normal result. All cases were subjected to routine biochemical liver function tests and serum antibodies to bilharziasis. The results showed that, ALT and AST were highly significant difference in group hepatitis C only compared with control group which showed normal results. The other liver functions such as ALP, TB and DB were high in patients with hepatitis C and Biharziasis compared with control group with statically significant difference P<0.05 . Also, the results showed histopatholigical changes (fibrosis and cirrhosis) in patients with Hepatitis C and Hepatitis C and Biharziasis after taking liver biopsy from both patients.

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