Ameliorative effect of olive leaves extract on hepatotoxicity and oxidative stress in streptozotocin-induced diabetic rats.

Document Type : Original Article

Authors

1 Zoology Dep. Faculty of Science, Menoufia University, Menoufia, Egypt

2 Zoology Dep. Faculty of Science, Damanhour University, Damanhour, Egypt

Abstract

Diabetes mellitus (DM) is a chronic metabolic disease. Olive leaves consists of phenolic compounds, flavonoids and volatile oil. The aim of this study was to evaluate the anti-diabetic and the curative effect of olive leaves extract on streptozotocin-induced diabetic rats. Forty male rats were divided into 4 groups, Group I; Animals were served as control. Group II; Animals were received oral Olive leaves extract (OLE) 0.5 mg/kg of body weight/day. Group III; Animals were injected intraperitoneally with a single dose of streptozotocin (STZ) (45mg /kg of body weight) to induce diabetes. Group IV, Animals were received a single dose of streptozotocin and after 7 days received Olive leaves extract for four weeks. The results indicatet that injection of STZ provoked a significant increase (P<0.005) in serum ALT, AST and lipids. Moreover, Serum malondialdehyde was increased and the antioxidant enzymes SOD and CAT decreased. Histopathologically, the OLE group didn't show any histopathological changes. Diabetic animals showed many histopathological changes in liver e.g. destruction of liver architecture, congestion of blood vessels, Leucocytic infiltration, and cytoplasmic vacuolization of hepatocytes. The pancreas showed severe damages in the pancreas architecture and atrophy of β-cells. When animals treated with OLE, an improvement was observed in the biochemical parameters and liver and pancreas histology of these animals. It is concluded that OLE exhibited a pronounced hypoglycemic, hypolipidemic and ameliorative effects in diabetic rats and this is may be attributed to the presence of its phenolic compounds.

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