Effect of calcium ionophore A23187 on the sperm in intracytoplasmic sperm injection.

Document Type : Original Article

Authors

1 Zoology Department, Faculty of Science, Cairo University, Egypt.

2 Andrology Department, Faculty of Medicine, Cairo University, Egypt

3 Obstetrics & gynecology department, International Islamic center for population studies and research, Al-Azhar University

Abstract

The present study evaluated the effect of calcium ionophore A23187 on sperm in intracytoplasmic sperm injection (ICSI) cycles using sperm from different sources. The 80 cycles evaluated were divided into four subgroups according to sperm quality and origin (normospermia- oligoathenoteratospermia–epidermal–testicular), subgroups were further split into experimental groups, depending on whether the spem treated or not treated with calcium ionophore. For each experimental subgroup, ICSI outcomes were compared between groups. In conclusion we found that using calcium ionophore increase the fertilization rate in case of sperm treatment with calcium ionophore before ICSI for oligoathenoteratospermia (OAT) & testicular subgroups, with enhancing embryos quality in testicular subgroup only

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