Effects of L-carnitine and Ginkgo biloba on Pentylentetrazol-induced liver damage and oxidative stress in rats.

Document Type : Original Article

Authors

1 Chemistry Department, Faculty of Science, Zagazig University, Egypt

2 Zoology Department, Faculty of Science, Tanta University, Egypt

Abstract

Pentylentetrazol (PTZ) kindling is an acknowledged models for epilepsy. The current study aimed to determine the possible protective and ameliorative effects of Lcarnitine and Ginkgo biloba (GB) against PTZ induced liver injury and oxidative stress in male rats. A total of 80 male albino rats were equally divided into eight groups; 1st group was the control; 2nd and 3rd were GB and Lcarnitine groups, respectively; 4th group was pentylenetetrazole rat group and the 5th and 6th groups were pre and post treated PTZ with L-carnitine groups respectively; the 7th and 8th groups were pre and post treated PTZ with GB respectively. Serum ALT, AST, ALP and MDA in liver tissue were significant increase in PTZ group when compare with control, while serum ALB and CAT, SOD, GST and TAC in liver tissue were significant decrease in PTZ group when compare with control. On other hand post and pre-treatment with L-carnitine and GB improved these parameters. Our results revealed that the treatment with L-carnitine improved these parameters more than GB and the results of post treatment were better than pre-treatment.

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