Immunological study for Helicobacter pylori bacteria in Egyptian patients.

Document Type : Original Article

Authors

1 Botany Department, Faculty of Science Benha University, Benha, Egypt.

2 Parasitology and Blood Research Department, National Organization for Drug Control and Research (NODCAR), Cairo, Egypt.

3 Microbiology Department, National organization for Research and Control of Biologicals (NORCB),Cairo, Egypt.

Abstract

Helicobacter pylori (H. Pylori) are a helix shaped, microaerophilic, Gram-negative, flagellated bacteria. H. Pylori and mankind have an ancient relationship for at least 50,000 years. Commonly the first noninvasively testes used for H. pylori infection’s detection were immunological tests like blood antibody test and stool antigen test. We investigated the more efficient susceptibility immunological test for detection of H.pylori infection in adult Egyptian patients by comparing the results of H. Pylori IgA (HpIgA), IgG in serum blood (HpIgG) and H.pylori Ag in stool (HpSAg) for 30 adult patient against control group using ELISA technique. The results showed that each test could be used successfully for diagnosis of H. pylori. Finally HpSAg showed reliable results with high sensitivity (> 95%) followed by HpIgG (87.5%), while HpIgA showed the lowest sensitivity (37.5%). Our findings confirms the use of the mentioned immunological tests for detecting them H. Pylori infection and suggest the use H. Pylori Ag in stool as the most economic, sensitive and reliable method alone or followed by IgG antibody test as confirmatory test to be the first choices for early diagnosis of H. Pylori especially in developing countries.

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