Effects of propolis on histopathological and immunohistochemical alterations in testes of thyroidectomized rat.

Document Type : Original Article

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Zoology Department, Faculty of Science, Tanta University, Tanta 31527, Egypt

Abstract

The thyroid hormones, triiodothyronine (T3) and its prohormone, thyroxine, are secreted by the thyroid gland which are responsible for the regulation of metabolism in all body tissues. This work aimed to study the histopathological, immunohistochemical and biochemical changes in the adult rat testes after thyroidectomy, in addition to the role of propolis in reducing these changes. Twenty five male Wistar rats were assigned randomly into equal (5) groups; control, sham operated, shamed propolis, thyroidectomized, thyroidectomy treated with propolis. Levels in compare to control the thyroidectomized rats showed significantly decrease in serum T3 and increase in TSH levels. Degeneration and increase in the seminiferous tubules lumen also noticed. Immunohistochemical results showed a remarkable reduction of proliferating cell nuclear antigen (PCNA) and Ki-67 in spermatogonia of thyroidectomized rat testes as compared with control group. The results revealed that, propolis has an ameroliating role on thyroidectomized rats testes by decreasing damage.

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