Effect of calcium hypochlorite as a source of hypochlorous acid in ameliorating cyclophosphamide-induced pulmonary and cardiac injury in mice

Akl, Maher M.; Nazmy, Entsar A.; El-Khouly, Omar A.

doi:10.21608/jbaar.2022.259963

Effect of calcium hypochlorite as a source of hypochlorous acid in ameliorating cyclophosphamide-induced pulmonary and cardiac injury in mice

Document Type : Original Article

Authors

¹ Faculty of Science, Mansoura University, 35516, Mansoura, Egypt

² Critical Care and Emergency Department, Kafr ElSheikh Directorate of Health, Ministry of Health and Population, Egypt

³ Faculty of Pharmacy, New Mansoura University, New Mansoura, Egypt.

10.21608/jbaar.2022.259963

Abstract

Acute respiratory distress syndrome (ARDS) is recognized to be accompanied by severe lung and heart complications. This study aimed to demonstrate the efficacy of Calcium hypochlorite in cyclophosphamide (CP)-induced pulmonary and cardiac injury in mice. The CP-induced toxicity in the lung and heart is like that caused by ARDS. Calcium hypochlorite significantly attenuated doth lung and heart functionality and significantly reduced the CP-induced perivascular inflammation, congestion of blood vessels, and severe morphological changes of the alveolar wall. It also exerts anti-inflammatory and antioxidant effects on CP-induced pulmonary and heart toxicity. Given these results, calcium hypochlorite successfully ameliorates ARDS symptoms rendering calcium hypochlorite to be a promising agent to be tested in models of pneumonia caused by bacterial or viral infections, including those of acute respiratory distress syndrome (ARDS).

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