Circulating MicroRNA-34a as a Promising Marker for Early Detection of Heart Failure Diseases in Egyptian Patients

Document Type : Original Article

Authors

1 Molecular Biology Department, Genetic Engineering and Biotechnology Research Institute, University of Sadat City, Egypt.

2 Laboratory Department, National Heart Institute, General Organization for Teaching Hospitals and Institutes, Egypt

3 Critical Care Department, National Heart Institute, General Organization for Teaching Hospitals and Institutes, Egypt.

4 Environmental Studies and Research Institute, University of Sadat City, Egypt.

5 Laboratory Department, National Heart Institute, General Organization for Teaching Hospitals and Institutes, Egypt.

Abstract

Heart failure has been considered in the last few years as a major factor in global mortality. Heart failure is known as the reduced ability of the heart muscle to fill or/and to pump adequate blood. Finding a diagnostic biomarker is necessary to help in the early diagnosis of heart diseases. MicroRNAs are new biomarkers that have been used for early diagnosis of various diseases. The work aims to study miR-34a in patients with heart failure and assess its diagnosing role. In this work, a total of (120) subjects were divided into three groups as the following, the control group (n=20) of healthy individuals, group II (n=50) the patients with heart failure post myocardial infarction & group III (n=50) the patients with heart failure without myocardial infarction history. microRNA-34a expression showed high expression and significant elevation (P- value < 0.5) in group-II (31.67±11.8 fold) and group-III (27.31±12.4fold) compared with group-I (1.47±0.7 fold). Our results showed that microRNA-34a plays a critical role in patients with heart failure disease and can be used as a biomarker for the diagnosis of early stages of heart failure disease.

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