Role of Salvia hispanica seeds extract on Ehrlich ascites model induced liver damage in female mice

Document Type : Original Article

Authors

1 Biotechnology Research Center, Al-Nahrain University, Baghdad, Iraq.

2 College of Science , Al-Nahrain University, Baghdad, Iraq.

3 Zoology department, faculty of science, Tanta university

Abstract

Because the Ehrlich ascites carcinoma (EAC) model can accurately predict survival time and is successful in creating neoplastic cells, it is frequently employed in experimental cancer studies. The present work is designed to investigate The antitumorous properties and therapeutic potential of Chia (Salvia hispanica) seeds extract (ChSE) in inhibition of EAC induces liver toxicity and tissue injury. All is all of Forty female swiss albino mice were equally separated into four cohorts (Gp1, control group; Gp2, CHSE group; Gp3, EAC group; Gp4, EAC+ChSE). Current results revealed that; EAC caused a notable increase in serum Aspartate aminotransferase (ALT), alanine aminotransferase (AST),alkaline phosphatase (ALP) activities, body weight, liver weight, liver injury and a significant depletion in albumin and total proteins as in contrast to the control Gp. Post treatment of EAC with CHSE (EAC+ChSE) induced a significant depletion in serum ALT ,AST ,ALP , body weight, liver weight, liver injury and a notable rise in albumin and total proteins as compared to EAC Gp. One may draw the conclusion that ChSE possesses the capacity liver protective effect against EAC cells induced liver injury and signposts about the potential benefits of ChSE in the treatment of liver toxicity.

Keywords

Journal of Bioscience and Applied Research

Articles in Press, Accepted Manuscript
Available Online from 02 May 2024

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