Study of αvß3 integrin gene expression in the endometrium of women with unexplained recurrent Spontaneous abortion

Document Type : Original Article

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College of Applied Medical Sciences /University of Kerbala, Iraq

Abstract

Background: In 50% of cases, the pathogenesis of unexplained recurrent Spontaneous abortion (URSA) is still unclear. ` We assess the αvbeta3 integrin gene expression in fertile and RSA-afflicted women. Methods: Endometrial tissues (biopsies) (30 samples) divided into 15 RSA cases and controls (15) healthy through menstrual cycle in the mid-luteal period. The period of data collection was March 2022–December 2023. The αvß3 gene expression was examined and in compression to fertile women using (qRT-PCR). Results: The relative gene expression of αvß3 integrin was significantly decreased (p-value < 0.05) in RSA women in compression to control subjects. The reduction of αvß3 integrin might have an essential role in the pathogenesis of RSA. Conclusion: Comparing women with unexplained RSA to controls, the expression of integrin was considerably lower. Our results highlight the necessity of additional molecular examination of the endometrial tissue in afflicted women.

Keywords

Journal of Bioscience and Applied Research
Volume 10, Issue 5 - Serial Number 5
Special issue: The Third International Scientific Conference for Pathological Analyses College of Science, University of Basrah, Iraq February 14 – 15, 2024
December 2024
Pages 63-67

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