New AZO Compounds Derivatives Based on 4- chloro-2-((5-formyl-2-hydroxy-3-methoxyphenyl) diazenyl)benzenesulfonamide: Preparation, diagnostic, Spectroscopic, Antioxidant and Antimicrobial efficiency

Document Type : Original Article

Authors

Department of Chemistry, College of Science, University of Basrah, Basrah, Iraq

Abstract

In this study, two series of compounds have been prepared based on azo compound 4-chloro-2-((5-formyl-2-hydroxy-3-methoxyphenyl)iazinyl) benzene sulfonamide (A1) which prepared by diazotization of 2-amino-4-chlorobenzen sulfonamide and 4-hydroxy -3-methoxy benzaldehyde (vanillic aldehyde). The new azo (A1) subsequently reacted with amine and sulfa drugs such as 4-bromoaniline, sulfanilamide, sulfadiazine, and sulfathiazole to form corresponding azo-azomethine compounds as a first series. The reaction of this new azo-azomethine with thioglycolic acid with the participation of zinc chloride afforded thiazolidinone (MO and MS) as a second series. The prepared materials have been diagnosed with elemental analysis and various spectroscopic methods, spectroscopic techniques, such as IR, 1HNMR, 13CNMR, and Mass. All the new compounds were evaluated for their antioxidant using the free radical scavenging (DPPH) method. The antibacterial activities were studied in in-vitro as opposed to gram-positive (staphylococcus aureus) and gram-negative (Escherichia coli) by utilizing an agar diffusion process, at different concentrations to calculate MIC. Furthermore, the antifungal potential opposed to fungal strains such as candida albicans was studied and showed good to moderate activity.

Keywords

Journal of Bioscience and Applied Research
Volume 10, Issue 5 - Serial Number 5
Special issue: The Third International Scientific Conference for Pathological Analyses College of Science, University of Basrah, Iraq February 14 – 15, 2024
December 2024
Pages 153-162

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