Testing for Cytomegalovirus (CMV) Infection in Patients with Previous Miscarriage: A Prospective Observational Study

Document Type : Original Article

Authors

1 Analysis and Laboratories Department, Higher Technological Institute of Applied Health Sciences in Sohag, Ministry of Higher Education, Cairo, Egypt

2 Biochemistry and Molecular Biology, Faculty of Pharmacy, Al-Azhar University, Asyut Branch, Egypt

3 Obstetrics and Gynecology Department, Faculty of Medicine, Sohag University, Egypt

Abstract

Background: One of the opportunistic viruses is cytomegalovirus (CMV), which is widely distributed and can infect individuals at any stage of life. It can result in significant pregnancy complications and is a primary cause of both perinatal and prenatal infections. Objective: This study suggested the necessity of conducting a CMV-IgG test and confirming the results with reverse transcriptase polymerase chain reaction (RT-PCR) technology for pregnant women to avoid miscarriage. Methodology: Eighty women who had miscarried were chosen. In addition to the chemical tests, including blood count tests and lupus anticoagulant level assessment, the CMV-IgG test was conducted, and the infection was confirmed by RT-PCR test. Result: Our study revealed that 52 (65%) of the 80 women who had miscarried did not have CMV infection. The remaining 28 (35%) cases of miscarried women were found to be infected with CMV using the ELIZA technique to detect CMV-IgG antibodies. The infection was confirmed by RT-PCR for CMV DNA. The results showed a high statistically significant relationship between the levels of white blood cells and the Lupus anticoagulant, as the percentage of white blood cells was lower in aborted women infected with CMV than in aborted women who were not infected with the virus. Also, the level of Lupus anticoagulant increased in aborted women who were not infected with CMV compared to those infected with the virus.

Keywords

Journal of Bioscience and Applied Research
Volume 10, Issue 6 - Serial Number 6
Special issue; SPBH-IC: Biomedical
December 2024
Pages 162-173

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