Application of Photoplethysmography for Vascular Health Assessment in Healthy Individuals: A Novel Methodology

Document Type : Original Article

Author

Department of Chemistry and Biochemistry, Al-Iraqia University/ College of Medicine -Baghdad, Iraq.

Abstract

The research investigates using photoplethysmography (PPG) for assessing endothelial function, crucial in understanding cardiovascular diseases. Factors such as smoking, high blood pressure, cholesterol, obesity, and diabetes significantly affect cardiovascular health by damaging blood vessels and increasing heart strain. It measured HbAIc, FBG, Lipid profile, and calculation BMI. Using the Flow-Mediated Dilation (FMD) method, which requires complex equipment and expertise, PPG offers a simpler alternative. By analyzing Pulse Transit Time (PTT) and Digital Pulse Wave (DPW) amplitude after induced blood flow increase (reactive hyperemia), PPG serves as a non-invasive measure for evaluating vascular health, indicating early signs of cardiovascular problems. Methods: 30 Healthy Adhering to ethical standards, the cross-sectional study involved males, ensuring a baseline of metabolic health through measurement of HbA1c, FBG, lipid profile, and calculation of BMI. The measurements were within a normal range. The methodology entailed a standardized protocol for inducing and measuring RH, with signal analysis performed via Lab Chart Pro 7® software.
Results: Significant findings include increases in PTT and DPW amplitude during RH, indicating PPG's efficacy in detecting endothelial function changes comparable to FMD. These results validate PPG's potential for broader clinical and research applications, given its simplicity and non-invasiveness.
In conclusion, PPG emerges as a promising tool for non-invasively assessing endothelial function, offering insights into vascular health and the progression of cardiovascular diseases. The study underscores the importance of innovative methodologies in enhancing cardiovascular disease management and prevention strategies.

Keywords

Journal of Bioscience and Applied Research
Volume 10, Issue 6 - Serial Number 6
Special issue; SPBH-IC: Biomedical
December 2024
Pages 195-202

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