Role of Homocysteine and water-soluble vitamins in Parkinson's disease: A case-control study in Iraq

Author

Department of Chemistry, College of Science, Mosul University, Iraq

Abstract

Parkinson's-disease (PD) is a neurological incident that becomes exacerbated with age. The research aims to investigate the role of Homocysteine, Vitamin B12, folic_acid, and other micronutrients in PD, focusing on how elevated homocysteine levels and deficiencies in these nutrients may contribute to neurodegeneration, and exploring their role in potentially intensifying disease progression and deteriorates patient outcomes.
A case-control study was conducted to examine various blood biomarkers in 200 participants grouped as 100 control and 100 PD patients (59% were female and 41% male), ages ranging from 43-67 years. About 52% of patients and 43% of the control group were smokers. Samples of venous blood were collected from each individual to measure levels of water-soluble vitamins (Vit B12 and folic acids), different types of micronutrients including iron, magnesium (Mg), phosphorus (Ph), and zinc (Zn), in addition to the measurement of Homocysteine level and glutathione. A highly significant_ decrease (P˂0.01) in all the measured biochemical parameters, except Mg, folic acid, and Homocysteine were significantly elevated in the patients' group compared to the control group. The results of the study conclude very highly significant sensitivity and specificity of Mg, folic acid, and Homocysteine in PD patients that confirm the significant role of those biochemical markers in the disease.

Keywords

Journal of Bioscience and Applied Research
Volume 11, Issue 1 - Serial Number 1
January- February- March
March 2025
Pages 9-19

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