New hydrophilic grafting cellulose based on amino-carboxylic acid: Synthesis and antibacterial evaluation

Document Type : Original Article

Authors

1 Chemistry Department-Faculty of Science-University of Kufa, Najaf, Iraq

2 College of Dentistry, Al-Muthanna University, Samawah 66001, Iraq.

3 Medical Laboratory Technology Department, College of Medical Technology, The Islamic University, Najaf, Iraq

4 ALmustaqbal University, College of Sciences, Department of Biochemistry Sciences

10.21608/jbaar.2025.353637.1140

Abstract

Background: There is a growing interest in developing the antibacterial properties of hydrophilic polymers. Methods: In this research, new grafting cellulose based on amino-carboxylic acids are obtained and their biological activities are evaluated. The sequences are started by treating cellulose with tosylate chloride to get 2, which further reacts with sodium azide. Results: To produce compound 3. Azide reduction to amino analog by sodium sulfide produces compound 4. The alkylation with chloroacetic acid compound 5 is obtained with amino-acid residue 5. Conclusions: Finally, extensive antibacterial studies have been performed against two types, Staphylococcus aureus and Escherichia coli. The results demonstrated that the novel derivatives may influence bacteria at low concentrations, and their water solubility could lead to them being biocompatible agents.

Keywords

Journal of Bioscience and Applied Research
Volume 11, Issue 1 - Serial Number 1
January- February- March
March 2025
Pages 214-222

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