New Grafting Starch Based on Triazolyl Aldehyde, Synthesis, and Antibacterial Study

Document Type : Original Article

Authors

1 Chemistry Department-Faculty of Science-University of Kufa, Najaf, Iraq

2 College of Dentistry, Al-Muthanna University, Samawah 66001, Iraq.

3 Medical Laboratory Technology Department, College of Medical Technology, The Islamic University, Najaf, Iraq

4 Department of Radiology and Sonography, College of Medical Technologies, Islamic University, Najaf, Iraq

5 ALmustaqbal University, College of Sciences, Department of Biochemistry Sciences

Abstract

Interest in the production of polymers with antibacterial properties is growing. In this study, a novel triazolyl aldehyde-based graftable starch was developed, and its biological activity was determined. The approach requires several steps, starting with the starch and tosyl chloride in pyridine to produce compound 2. The treatment of compound 2 with sodium azide created compound 3, containing an azide residue. Separately, compound 4 is formed by the reaction of 4-hydroxybenzaldehyde with propargyl chloride. The target product, the triazolyl aldehyde-based starch compound 5, was afforded through click chemistry by incorporating 3 and 4. All compounds were characterized using spectroscopic instruments. Finally, the antibacterial activity of grafted polymer 5 against Staphylococcus aureus and Escherichia coli was studied.

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