Investing Chemicals in Oleander Leaf Extract as an Anti-breast Cancer

Document Type : Original Article

Authors

1 Chemistry, Ministry of Education, Baghdad Education Directorate / First Al-Rusafa, Iraq

2 Chemistry, Ministry of Education, Babylon Education Directorate, Iraq

3 pharmacology and toxicology, Ministry of Agriculture, Babylon Agriculture Directorate, Babylon, Iraq.

Abstract

Cancer is still crucial for the whole world and is a total burden on health; it is the main thing that we should investigate and find new therapeutic ways of treatment. This study investigates Oleander's (Nerium oleander) leaf extract's possible anticancer effects on human breast cancer cells in a test tube. Our study evaluated the cytotoxic effects of Oleander leaf extract on the Michigan Cancer Foundation-7(MCF-7) using the MTT assay. The results were compared with their effects on normal human dermal fibroblasts (HdFn). Preliminary results show differential cytotoxicity, with the extract demonstrating greater toxicity to MCF-7 cells compared to HdFn cells. This suggests a degree of selectivity in its anticancer activity, a desirable characteristic in cancer therapeutics. The antioxidant potential of the extract was studied using the DPPH assay. An IC50 value less than 50 μg/mL indicates a strong antioxidant activity (The highest activity was documented at a concentration of 12.5 ), whereas an IC50 value above 100 indicates weak activity

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