Spectrophotometric Determination of Ambroxol by Chromotropic acid disodium salt dihydrate

R. Al - Araji, Riyadh; Shalan Al-Mushhdi, Abd Ali Abd Al-Hussein

doi:10.21608/jbaar.2025.374970.1185

Spectrophotometric Determination of Ambroxol by Chromotropic acid disodium salt dihydrate

Document Type : Original Article

Authors

¹ Department of Biology, College of Education for Pure Science, University of Wasit, Wasit, Iraq.

² Chemistry Department, Najaf Central Preparatory School for Boys, Ministry of Education, Iraq

10.21608/jbaar.2025.374970.1185

Abstract

An easy and prompt spectrophotometric method was proposed for the limitation of the drug Ambroxol substance containing the amine group by the organic reagent (4,5-Dihydroxynaphthalene-2,7-disulfonic acid disodium salt dihydrate).
When the reaction product gave a wavelength(469nm), and in optimal conditions for the reaction, a calibration curve was generated. The result was found that Beer's law was obeyed within concentration ranges of 2-18µg.mL^-1 of Ambroxol, and the other parameter was calculated. The molar absorptivity was 0.8287X10⁴ L.mol^-1.cm^-1, Sandell's sensitivity was 0.0128 μg.cm^-2, R.S.D% was 0.6520 %, with a correlation coefficient of 0.9967 for Ambroxol. The interferences were studied; they didn't affect on concentration limitation of Ambroxol. The method was successfully applied for the determination of Ambroxol in pharmaceuticals.

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