Magnesium oxide nanoparticles' antibacterial and antibiofilm-forming properties against MDR P. mirabilis isolated from various clinical infections

Background: P. Mirabilis has been connected to several respiratory disorders in humans, skin, ear, eye, and gastrointestinal disorders. Due to the possibility of catheter-associated UTIs, this is particularly worrisome for patients receiving prolonged urine catheterization in an indwelling device. The unique ability of P. mirabilis is to form a special class of biofilms, which are usually crystalline. complicates these infections. Additionally, P. mirabilis resistance is growing more complex and serious every year, particularly the manifestation of resistance to carbapenem drugs, making disease prevention and control more difficult. Objective: The purpose is to look at how magnesium The impact of oxide nanoparticles on MDR P. mirabilis that has been isolated from various clinical infections.  Approach: Individuals suffering from a range of illnesses, including blood infections, burns, urinary tract infections, and otitis media, yielded 120 isolates of P. mirabilis.  The University of Kufa's Faculty of Science's Advanced Microbiology Laboratory received specimens from patients who were admitted from the Hospital. Results: The results showed that antibacterial susceptibility test and biofilm formation showed that 60 isolates of P. mirabilis are MDR. The results proved that MgO NPs are effective in inhibiting MDR P. mirabilis demonstrated the inhibitory of P. mirabilis progressively grows when increasing MgO NP and decreases biofilm formation with increasing MgO NP concentrations using various concentrations (100, 200, 300, and 400) μg/ml. Conclusion: showed inhibitory MDR P. mirabilis progressively grows with more MgO NPs when employing varying doses of MgO NPs, and reduces the production of biofilms as MgO NP concentrations rise.