Assessment of Serum Hepcidin and Its Association with Hematological Parameters in Acute Lymphoblastic Leukemia

Document Type : Original Article

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University of Kufa / Faculty of Sciences, Najaf, Iraq

Abstract

The most prevalent form of childhood cancer, acute lymphoblastic leukemia (ALL), is distinguished by the buildup of malignant cells and their multiplication lymphocytes in the bone marrow. Imbalances in immune expression and iron homeostasis are frequently observed in acute leukemia. The research experiments were carried out from December 2023 to November 2024 in the Biology Department of the University of Kufa's Faculty of Science.  Individuals with acute lymphoblastic leukemia (ALL) who had treatment at the National Center for Teaching Laboratories Hospital in Baghdad Medical City and the National Hospital for Oncology and Hematology in Najaf. Since iron is a necessary component of blood cells, serum hepcidin levels are used to monitor the body's iron status.  According to the study's findings, newly diagnosed ALL patients had noticeably higher blood hepcidin levels.  Newly diagnosed acute lymphoblastic leukemia patients had noticeably higher white blood cell counts.  In this study, individuals with acute lymphoblastic leukemia had low red blood cell counts.

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