O- methylation mediated by COMT enzyme is an important mechanism for inactivating Catechole Estrone (CE) which including 2- HE and 4- HE and transform it to 2-ME and 4-ME which act as anti- tumor genesis. This study aimed to investigate the association between the polymorphism in COMT genotype and the breast cancer risk in (40) young patient's women aged between (20-39) years were diagnosed and confirmed with breast carcinoma at AL- Sadder hospital in Missan, and (40) healthy control women aged between (18-39) years in the period between September -2009 to April -2010 Odds ratios(OR) and confidence interval (CI) were calculated in level significant P < 0.05. The statistical analysis showed no association between the breast cancer risk in young women and homozygous wild (Met/Met) genotype with an OR of 0.63(95%CI= 0.248 - 0.552 ), also with heterozygous (Val/Met) genotype with an OR of 0.93 (95%CI= 0.155 - 0.44 ), and when a combination (Met/Met + Met/Val) genotype with an OR of 0.78 (95%CI= 0.559-0.841), compared to homozygous mutant (Val/Val) genotype. No significant differences in frequency of low activity alleles between cases and controls, indicating the polymorphism as a single factor may not contribute to breast carcinogenesis in young women.
Mraissl, A. (2018). Breast cancer risk associated with genotype polymorphism of COMT gene in young women. Journal of Bioscience and Applied Research, 4(4), 453-458. doi: 10.21608/jbaar.2018.152798
MLA
Abbas Ch. Mraissl. "Breast cancer risk associated with genotype polymorphism of COMT gene in young women", Journal of Bioscience and Applied Research, 4, 4, 2018, 453-458. doi: 10.21608/jbaar.2018.152798
HARVARD
Mraissl, A. (2018). 'Breast cancer risk associated with genotype polymorphism of COMT gene in young women', Journal of Bioscience and Applied Research, 4(4), pp. 453-458. doi: 10.21608/jbaar.2018.152798
VANCOUVER
Mraissl, A. Breast cancer risk associated with genotype polymorphism of COMT gene in young women. Journal of Bioscience and Applied Research, 2018; 4(4): 453-458. doi: 10.21608/jbaar.2018.152798