Study of Some Types of Bacteria and application of biological activity for some new Heterocyclic Compounds containing nitrogen Derivatives

Document Type : Original Article

Authors

1 Faculty of Medicine, Department of biochemistry,Jaber ibn Hayyan for Medical and pharmaceutical Sciences University, Iraq.

2 Department of chemistry ,College Education for Girls, University of Kufa, Iraq.

Abstract

This broadside includes a preparation of certain bioheterocyclic multifaceted derivatives starting: 6-bromo-2-hydroxy napthaldehyde, by the reaction between 2-amino-5-bromo pyrimidine with 6-bromo-2-hydroxy napthaldehyde, to produce a Schiff base derivative (S). The latter compound was used as an important substance to prepare six new heterocyclic derivatives that have a pyrimidine ring. Also, newly synthesized compounds were characterized by spectral data (FTIR, ¹H NMR, ¹³C NMR), and all the prepared derivatives were studied on four types of bacteria (Staphylococcus aureus and Escherichia coli, Enterococcus faecalis, Pseudomonas aeruginosa), by paper technique disks. Biological capacity tests for these derivatives revealed favorable findings.

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